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KMID : 1038120210540040589
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Clinical Endoscopy
2021 Volume.54 No. 4 p.589 ~ p.595
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Cholecystitis after Placement of Covered Self-Expandable Metallic Stents in Patients with Distal Malignant Biliary Obstructions
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Watanabe Masafumi
Okuwaki Kosuke
Woo Jun
Kida Mitsuhiro
Imaizumi Hiroshi
Iwai Tomohisa
Yamauchi Hiroshi
Kaneko Toru
Hasegawa Rikiya
Kurosu Takahiro
Minato Naoki
Haradome Hiroki
Koizumi Wasaburo
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Abstract
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Background/Aims: Cholecystitis can occur after the placement of covered self-expandable metallic stents for distal malignant biliary obstructions. We aimed to identify risk factors for cholecystitis following covered self-expandable metallic stent placement.
Methods: We investigated risk factors related to cholecystitis following covered self-expandable metallic stent placement in 118 patients with distal malignant biliary obstructions between January 1, 2015 and April 30, 2019. Endoscopic assessments and tumor invasion to the arteries feeding the gallbladder were determined by a pancreaticobiliary endoscopist and a radiologist, respectively.
Results: The median patient age was 72 years (men, 61.0%). The flow of the contrast agent into the gallbladder and tumor involvement in the orifice of the cystic duct were observed in 35 (29.7%) and 35 (29.7%) patients, respectively. During the observation period (median, 179 days), cholecystitis occurred in 18 (15.3%) patients. Multivariate analysis revealed the flow of the contrast agent into the gallbladder (p=0.023) and tumor involvement in the orifice of the cystic duct (p=0.005) as significant independent risk factors associated with cholecystitis.
Conclusions: The flow of the contrast agent into the gallbladder and tumor involvement in the orifice of the cystic duct are potential independent risk factors for cholecystitis following the placement of covered self-expandable metallic stents. A follow-up prospective study is warranted to validate their influence.
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KEYWORD
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Cholecystitis, Endoscopic retrograde cholangiopancreatography, Malignant biliary obstruction, Risk factors, Self-expandable metallic stents
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